Dead Space 2 seems to have native pad support, and works find for me with my dual action gamepad. In case I have any problems when running it with Logitech Rumblepad 2, I'll get back with an update...To play it safe you can always download and add the following in your installed directory...
http://xinput.googlecode.com/files/xbox360cemu.v.3.0.rar
\Program Files\EA Games\Dead Space 2\
dinput8.dll
xbox360cemu.ini
xinput1_3.dll
xinput9_1_0.dll
And off you go on an great journey...